After enabling this feature, PUA protection blocking takes effect on endpoint clients after the next signature update or computer restart. Signature updates take place daily under typical circumstances. PUA will be blocked and automatically quarantined.
Set the policy value for Computer Configuration >> Administrative Templates >> Windows Components >> Windows Defender Antivirus >> 'Configure Detection for Potentially Unwanted Applications' to 'Enabled' and 'Block'.
The following resource is also helpful.
This security hardening control applies to the following category of controls within NIST 800-53: System and Information Integrity.This control applies to the following type of system Windows.