This setting specifies whether users can open, view, edit, or save files saved in the specified format. Enabling block of the specified format mitigates zero-day security attacks (which are attacks that occur between the time that a vulnerability becomes publicly known and a software update or service pack is available) by temporarily preventing users from opening specific types of files and to prevent a user from opening files that have been saved in earlier and pre-release (beta) Microsoft Office formats.
Set the policy value for User Configuration -> Administrative Templates -> Microsoft Excel 2013 -> Excel Options -> Security -> Trust Center -> File Block Settings 'Excel 4 worksheets' to 'Enabled: Open/Save blocked, use open policy'.
The following resource is also helpful.
This security hardening control applies to the following category of controls within NIST 800-53: System and Communications Protection.This control applies to the following type of system Windows.